beta 2 Adrenergic Receptor anticorps

N° du produit ABIN1105514

L’anticorps Souris Monoclonal anti-beta 2 Adrenergic Receptor a été validé pour EIA, Func et ELISA (Detection). Il convient pour détecter beta 2 Adrenergic Receptor dans des échantillons de Humain, Rat et Cobaye.

Aperçu rapide pour beta 2 Adrenergic Receptor anticorps (ABIN1105514)

Antigène: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Reactivité: Humain, Rat, Cobaye

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta 2 Adrenergic Receptor est non-conjugé

Application: Enzyme Immunoassay (EIA), Functional Studies (Func), ELISA (Detection)

Clone: 6H8

Détail du produit anti-beta 2 Adrenergic Receptor anticorps

Specificité: The monoclonal antibody 6H8 recognizes Human beta-2-Adrenoceptor.

Réactivité croisée (Details): Species reactivity (tested):Human, Rat, Guinea Pig.

Purification: Protein G

Immunogène: Free peptide Beta2-H19C

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur beta 2 Adrenergic Receptor

Antigène: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Autre désignation: beta-2 Adrenergic Receptor

Sujet: The b -adrenoceptors can be divided into b1, b2, b3 and b4-adrenoceptors defined in terms of agonist potencies, b2-adrenoceptors displayed a higher selectivity for nor-adrenaline than for adrenaline. B2-receptors are mainly postsynaptic and are located on a number of tissues including blood vessels, bronchi, GIT, skeletal muscle, liver and mast cell. Activation results in vasodilatation, bronchodilation, relaxation of the GIT, glycogenolysis in the liver, tremor in skeletal muscle and inhibition of histamine release from mast cells. Transduction is via G-proteins coupled to the intracellular second messenger adenylate cyclase. B-receptors are positively coupled to adenylate cyclase via activation of Gs G-protein, however activation of the b2-adrenoceptors results in stimulation and inhibition of adenylate cyclase. The b2-receptor selective agonists are widely used in the treatment of asthma and other related bronchospastic conditions. They are commonly used in the treatment of angina pectoris, cardiac arrhythmia and for the long-term treatment of patients who survive myocardial infarction. B-receptor antagonists have also been used as anti-hypertensive for a number of years. Beta -blockers have also proven useful in the treatment of conditions such as migraine, anxiety disorders, hyperthyroidism, alcohol withdrawal and when applied topically are useful in the treatment of glaucoma and ocular hypertension.Synonyms: ADRB2, ADRB2R, B2AR, Beta-2 adrenoreceptor

ID gène: 154

NCBI Accession: NP_000015

UniProt: P07550

Pathways: cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation